For 5-amino-1MQ specifically: Preclinical studies have not prominently described heart rate elevation as a dominant signal The mechanism (NNMT inhibition, NAD+ preservation) does not have the same direct cardiac implications as nuclear receptor agonism Human cardiovascular data at clinically relevant exposures are limited For physicians, the current evidence base does not support a major cardiovascular safety flag, but the limited human dataset means confident statements are premature
2020;886 doi: 10.1016/j.ejphar.2020.173412
Cell 92 , 735745 (1998)
TA Plant Stem Cell Extract, Glutathione, Placantal Protata, Licorice Extract, Peony, Tyrosine, Scutellaria, Saxifraga, Arbutin, Kojic Acid, FD&C Blue No
Sequence: Gly-His-Lys, with high-affinity Cu(II) binding Plasma levels fall from ~200 ng/mL at age 20 to ~80 ng/mL at 60 Modulates expression of ~4,000 human genes (Pickart et al., 2012) Active in wound-healing, fibroblast proliferation and antioxidant defence assays Sequence H-Gly-His-Lys-OH (Cu complex) Molecular weight 340.39 g/mol (free tripeptide)
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