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For that reason, tesamorelin should not be used by test subjects that suffer from an active malignancy

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This makes them water-soluble and able to be excreted through urine or feces.[ref] Essentially, these two steps need to work in tandem: Phase I : The CYP1B1 or CYP1A1 enzyme breaks down estradiol into the catechol estrogen metabolites

Mechanistic rationale is a starting point, not a conclusion