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The peptide also appears to have some direct effects on peripheral tissues beyond the central nervous system, including potential metabolic effects, cardiovascular influences, and immunomodulatory properties

Chen ML, Yi L, Zhang Y, et al

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Many researchers find their optimal dose between 7.5 mg and 10 mg

[51] The government of Australia prohibits the sales of such kavalactone extracts, and only permits the sale of kava products in their natural form or produced with cold water

Ashtary-Larky, D., et al