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Recent studies suggest that cancer cells are under increased oxidative stress caused by oncogenic transformation, leading to metabolic alterations that result in ROS production 56

Glutathione, on the other hand, is a tripeptide composed of three amino acids: L-glutamic acid, cysteine, and glycine

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Nelson DB, Godoy MCB, Benveniste MF, Shewale JB, Spicer JD, Mitchell KG, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG , Roth JA, Antonoff MB

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To confirm that the toxicity was due to depletion of GSH, we supplemented 2-AAPA treated zoospores with either GSH or GSSG (6)