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That last point is easy to miss

Argireline appears to exert these functions when applied topically, without the need for injectionshence it being dubbed Botox in a Bottle. It is often marketed as a gentler, safer alternative to the botulinum toxin [3, 25]

This inconsistency can complicate literature reviews and meta-analyses

b , Representative bright field images of Huh7 cells treated with vehicle and indicated inhibitors for 72 h

Rubber band ligation

Activation of the AMPK-Sirtuins-PGC1 pathway promotes mitochondrial biogenesis and function while regulating fission, fusion, and mitophagy processes, ultimately reserving organelle quality [86]