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4.9 Addressing publication bias and negative outcomes While the majority of studies cited in this review report positive findings regarding the effects of natural compounds in AD models, the potential influence of publication bias must be acknowledged

By attaching a larger molecule, like a polyethylene glycol (PEG) chain (a process called PEGylation), scientists can make the peptide too large to be easily filtered by the kidneys and can also sterically hinder the approach of degrading enzymes

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Alshehri S, Ahmad SF, Albekairi NA, Alqarni SS, AlHarbi NO, AlAyadhi L, Attia SM, Alfardan AS, Bakheet SA, Nadeem A (2023) Thioredoxin 1 and thioredoxin reductase 1 redox system is dysregulated in neutrophils of subjects with autism: in vitro effects of environmental toxicant, methylmercury

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