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After uptake by cancer cells, Pt (IV) prodrugs are reduced by intracellular GSH to produce active Pt (II) complexes, leading to the exhaustion of GSH

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The expression of genes for a series of antioxidant-related enzymes (-glutamylcysteine synthetase, GSH reductase, glutathione- S -transferase, GSH peroxidase, and superoxide dismutase) in diverse tissues was upregulated by these supplements [35]

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