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Petersburg, Russia Initial research in 1980s at Institute of Bioregulation and Gerontology Derived from studying pineal gland peptides and aging Over 40 years of Russian research (but limited Western studies) Inspired by observation that pineal gland function declines with age Why developed: Soviet/Russian focus on longevity research Searching for ways to extend healthy lifespan Understanding cellular aging mechanisms Pineal gland's role in aging and circadian rhythms Goal: Create synthetic peptide mimicking natural bioregulators Epithalon vs epithalamin: Epithalamin: Natural polypeptide complex from pineal glands (bovine) Epithalon: Synthetic tetrapeptide mimicking epithalamin's active component Epithalon more practical (synthetic production, consistent quality) Both target similar anti-aging pathways Learn peptide fundamentals and how peptides work at SeekPeptides to understand Epithalon's unique mechanisms

Early research, mostly done on different groups of older mice, found that FOXO4-DRI can help heal tissues, make organs work better, and reduce inflammation related to aging (6)

Starting slowly is wise

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403.9 g/mol Peptide Length: 3 amino acids Purity: 99.0% (validated by Certificate of Analysis) Appearance: Blue to blue-green lyophilized powder Solubility: Fully soluble in water (HO) Quality Verification: Confirmed by RP-HPLC analysis Storage Conditions: Store dry at 28 C

John Enn discovered an exopeptide in the saliva of the Gila monster which he named exendin-4