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Both can potentially exacerbate this condition

PLoS One 10 , e0127527 (2015)

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Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes

The female mice (homozygous for Hba tm1(HBA)Tow and heterozygous for Hbb tm2(HBG1,HBB*)Tow and Hbb tm3(HBG1,HBB)Tow [h/h:: A / S ], sickle-cell trait mice) and male mice (homozygous for both Hba tm1(HBA)Tow and Hbb tm2(HBG1,HBB*)Tow [h/h:: S / S ], sickle SCD mice) were bred to generate SCD mice

They also produce IL-10 and transforming growth factor (TGF-), which together inhibit macrophages and dendritic cells, decrease MHC II expression, and decrease Th1 cytokine release