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Since reperfusion used to treat IS causes additional damage in brain cells, including the accumulation of excess oxygen radicals and activation of apoptosis, the discovered therapeutic effects of ACTH(69)PGP allow us to highly appreciate the possibility of its clinical use after the administration of thrombolytics (e.g., tPA) or mechanical thrombectomy

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Halberstadt et al [26] used a second gradient of 7%, 11%, 13% and 16% (w/v) iodixanol at 800 g for 20 min