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The GSTP1 rs4147581 is in linkage disequilibrium with rs1695 (D = 0.99, R 2 = 0.44 in Admixed American populations, including Colombians), a common nonsynonymous SNP that changes the 105th amino acid from isoleucine to valine, altering the substrate binding site of GSTP1 38

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In a randomized clinical trial including 73 children aged between 1 and 18 years, with at least 5% skin involvement by AD, compared melatonin (3 mg/day) with placebo, both administered for a 4-week period, with a 2-week washout period