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It also helps to maintain a healthy nervous system and the cardiovascular function
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The hydroxyl groups in quercetins structure can donate electrons to neutralize ROS like superoxide radicals and hydroxyl radicals
Similarly, the neuroprotective effect of sinomenine on cognitive dysfunction following type 2 diabetes mellitus is achieved through the inhibition of ferroptosis in hippocampal neurons via the classical ferroptosis signaling pathway (epidermal growth factor/nuclear factor erythroid derived 2-related factor 2 (Nrf2)/heme oxygenase 1) and the microbiota-gut-brain axis [101]
PMCID: PMC9927842 Onyeakazi UM, Columb MO, Rosalind A, Kanakarajan S, Galley HF (2024) Melatonin treatment has consistent but transient beneficial effects on sleep measures and pain in patients with severe chronic pain: the DREAM-CP randomised controlled trial
