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Specifically, there was an increase in the endoplasmic-reticulum-to-cytoplasm Zip7 mRNA and protein expression as well as phosphorylation, leading to elevated intracellular free zinc levels

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T ransient nausea, diarrhea, and mild irritation at the injection site have been reported as adverse undesirable effects in preclinical studies

Since apoptosis is defined by the NCCD as a caspase-dependent RCD [4], and considering the fact that eryptotic pathways dont culminate in activation of caspases [84], it has become clear that eryptosis is guided and executed alternatively

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