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For those without contraindications of vitamin B12, the potential benefits of vitamin B12 supplementation are often deemed to outweigh the associated risks

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

The 0.25mg starting dose differs from the 0.5mg week-five dose and the 1.0mg maintenance dose

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Understanding the pharmacology shapes the dosage logic