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Methods Rats were divided into five groups: H1 (control), H2 (single dose of Hg), H3 (continuous dose of Hg), H4 (single dose of Hg+ single dose of NAC), and H5 (continuous dose of Hg+ continuous dose of NAC)
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FIGURE 9 5 Conclusion Overall, GM toxicity resulted in profound kidney injury, attributed to oxidative stress, inflammation, AQP downregulation, and apoptotic cell death
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However, other researchers have argued that controversial issues exist because GPNA also inhibits other glutamine transporters, such as SLC38A1, and V-9302 is effective even in SLC1A5 knockout models 206,207
Presently, our understanding allows us to assert that the predominant methods of radiotherapy and cytostatic drugs may induce cellular senescence [54]
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