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Tirzepatide follows a weekly dosing schedule, and dose increases typically happen every four weeks during titration

This renders HBsAg an interesting therapeutic target as HBsAg is clearly distinct from proteins expressed in healthy liver tissue

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Mol Ther 28(2):479489

Upon tight binding to gastric epithelial cells, adhesins employ a range of effector proteins, including vacuolating cytotoxin A (VacA), cytotoxin-associated gene A (CagA), and cytotoxin-associated gene L protein (CagL), to manipulate host cell signaling and alter the behavior of gastric epithelial cells, thus promoting long-term colonization (Salama et al., 2013)