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Intracellular metabolic processes are essential for maintaining the normal physiological activities of bacteria, and an increasing body of research has demonstrated a significant association between metabolic alterations and the development of drug resistance

Di PierroMLuRUzzauSWangWMargarettenKPazzaniCet al

doi: 10.1007/s12031-016-0857-x

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In time, progression from NAFLD to fibrosis (scarring) and cirrhosis (scarring of the liver) can result in hepatorenal syndrome, a complication marked by severe kidney malfunction with reduced kidney blood flow and abdominal edema (ascites)

However, individuals with BTHS also experience endocrine and metabolic disturbances such as recurrent hypoglycaemia and delayed growth [45]