The compound has been the subject of decades of academic research literature on cellular redox biology, GSH/GSSG cycling kinetics, glutathione peroxidase and glutathione reductase enzyme mechanisms, phase II conjugation reactions in xenobiotic metabolism, and cellular thiol-disulfide chemistry
Anti-inflammation: It protects from acute lung injury by reducing inflammation, boosting glycolysis, and limiting ferroptosis [15]
Another issue is that polypharmacology can lead to off-target effects and interactions
Consequently, by disrupting this upstream network to inhibit the terminal apoptotic cascade, palmatine effectively mitigates the downstream sequelae of cell deathnamely, hepatic steatosis, inflammation, and metabolic dysfunction
Critical Reviews in Food Science and Nutrition, 63 (20), 46184635
found that decreased expression of isocitrate dehydrogenase 3 complex alpha subunit (IDH3) is associated with metabolic reprogramming