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This targeted, or regioselective, activation of IL-2 may help explain the broader improvements in neuroimmune integration and stress resilience observed in older biological systems

By influencing S-adenosylmethionine (SAM) levels, it also plays a role in epigenetic regulation and longevity-related gene expression, linking energy metabolism with cellular lifespan

Interpretations must account for the absence of any direct mechanistic crosstalk documented between these two molecules

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Tight junctions consist of four unique families of transmembrane proteins including occludin, claudins, junctional adhesion molecules, and tricellulin, and are considered one of the principal determinants of mucosal permeability (Fig

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