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The 2023 GRAS designation permits marketing as a dietary supplement ingredient but NOT as a therapeutic agent

Results The AngIV Analog D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 is More Metabolically Stable than Norleual (Nle-Tyr-Leu--(CH 2 NH 2 ) 3-4 -His-Pro-Phe (SEQ ID NO: 1): The AngIV-related peptidomimetic Norleual was previously shown to possess, anti-HGF/Met, anti-angiogenic, and anti-cancer activities (Yamamoto et al., 2010)

Room temperature: the danger zone Room temperature, typically 20 to 25C (68 to 77F), is hostile to reconstituted peptides

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