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The latter is consistent with the pseudotime analysis of our scRNA-seq data, showing that Vegfc expression is initiated in Esm1 + ECs during early steps of arterial specification and prior to Bmx expression (Supplementary Fig

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Our results revealed that altered metabolomic profiles might contribute to the pathogenesis and course of MS disease by modulating immuno-inflammatory responses in the peripheral system, which is essential for eliciting autoimmune responses in the central nervous system, thus resulting in the progression of MS

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