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These results show that the effect of inhibiting GSH synthesis acts on top of increased intracellular drug concentrations that are caused by ABCC1 loss and indicates that GSH is needed for efficient detoxification

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Ein dauerhaft gestrter Glutathionstoffwechsel kann somit viele Systeme in Schieflage bringen angefangen bei chronischer Erschpfung bis hin zu Krebserkrankungen oder neurologischen Strungen

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By restoring A1AT levels, augmentation therapy aims to slow down the progression of lung disease and reduce the risk of developing complications such as emphysema and increase survival