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414 Emerging drugs and uricosuric compounds Given the advancements in drug delivery systems and a deeper understanding of renal mechanisms and urate transporters, numerous novel therapeutic agents for managing hyperuricemia are currently in various stages of clinical development

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McEwen has defined allostatic load as the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine response resulting from repeated or chronic environmental challenge that an individual reacts to as being particularly stressful (287)

A study by Sarafian et al (1999) demonstrated significant dose-dependent increases in ROS production in vitro induced by marijuana cigarette smoke containing THC, which was manifested by higher nitrate levels measured in culture, compared with controls

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