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The disruption of the vital enzymatic steps associated with glutamine utilization by glutaminase inhibitors results in reduced availability of metabolic intermediates required for nucleotide synthesis, tricarboxylic acid (TCA) cycle replenishment, and redox balance maintenance, collectively inducing metabolic stress and compromising cancer cell viability [56]

No New Drug Application (NDA) or Biologics License Application (BLA) for BPC-157 has been submitted or approved by the agency

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In addition, overfitting of the models was low, since the performance was similar for both cross-validation and testing using the validation set

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