stroke and cigarette smoking boosts risk for rare, often fatal, bleeding Change in Smoking Behavior and

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Proposes a role for benzo[ a ]pyrene-7,8-diol-9,10-epoxideDNA adducts as causes of mutations found in the TP53 gene in lung cancer

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This supports hypothesis 2

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Smoking cigarettes may cause Grave's hyperthyroidism , a condition where the thyroid gland a part of the endocrine system produces excess amounts of the thyroid hormone