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It does so through an epigenetic mechanism, where FGF15/19 interacts with its target nuclear receptors, such as small heterodimer partner (SHP), which then recruits DNA methyltransferase-3a (DNMT3a) to the lipogenic gene loci, including FASN

10.1042/BCJ20160510 122 TianH.WangX.FangZ.LiL.WuC.BiD.et al (2024)

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