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Figure 4.12 Causes of Airflow Limitation in COPD Parenchymal destruction (emphysema) plays a smaller role in this irreversible component but contributes to expiratory airflow limitation and the increase in airways resistance in several ways

It acts as a mitochondrial protective agent, stabilizing mitochondrial structure, enhancing oxidative phosphorylation, reducing production of reactive oxygen species (ROS), and mitigating cellular damage in diverse models of mitochondrial dysfunction

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and getting hormone levels higher and higher could lead to unfortunate effects on your health