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In conclusion, OA pathogenesis is propelled by a metabolically dysregulated milieu, where obesity, oxidative stress, gut dysbiosis, and broader metabolic syndrome converge to create a self-perpetuating cycle of inflammation and tissue damage (Figure 1)

The term methylcobalamin in the claims includes methylcobalamin and equivalently active stereoisomers, and cyanocobalamin, hydroxycobalamin and adenocobalamin, and glutathionylcobalamin

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However, prioritizing non-pregnant subjects outside the extremes of age decreases the likelihood of unforeseen confounding variables

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