10.1007/s12017-017-8459-5 122 HadjadjS.CariouB.FumeronF.GandE.CharpentierG.RousselR.et al
In addition, degradation within the gastrointestinal tract and first-pass metabolism substantially reduce systemic bioavailability, and preclinical animal findings may not consistently predict human pharmacokinetics and efficacy ( in vivo transformation mechanisms to meet the stringent demands for safety, stability, reproducibility, and standardization necessary for clinical translation
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bifidum , which adhere to host cell surface glycolipids, thereby effectively blocking pathogenic bacteria from binding to the same receptors and preventing their colonization (163)
It may also support intestinal mobility in the removal of pathogenic bacteria, producing improvement of microflora balance and a well-maintained digestive system through colonisation of beneficial microbial populations (Bellikci-Koyu et al., 2019
