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L2-Cmu treatment improves female cardiac function Given the reported importance of IGF-1 signaling to the myocardium 27,28 , we next assessed the effects of IGF-1R antagonism on cardiovascular function by echocardiography (Fig

Inflammatory cytokines released by activated microglia and astrocytes (IL-1, TNF-, IL-6) upregulate the iron importer protein, DMT1, and downregulate the iron exporter protein, FPN1, promoting iron accumulation in neurons [179, 180]

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