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"What was clear, from just a number of studies throughout the 60s, particularly in the UK, was that smoking advertising, even if it was geared towards or notionally pitched at adults, portrayed smoking as cool, as sophisticated, as something that marked you as a fully grown adult, and so therefore appealed to youth and teenagers in particular," historian Thomas Kehoe tells ABC RN's Late Night Live

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Tobacco use weakens the lower esophageal sphincter, increases stomach acid production, and impairs the esophaguss natural ability to clear acid, creating a perfect storm for persistent and worsening reflux symptoms

Does nicotine affect D2 receptor upregulation