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Given the recently recognized regional and zonal heterogeneity of the BBB, future studies also need to take into account how these variations influence dysfunction and drug delivery efficacy across different brain regions

Moreover, glucocorticoid receptors appear to have diminished sensitivity in mood disorders, possibly due to elevation in inflammatory cytokines, thereby disrupting physiological feedback regulation on the HPA axis and immune system (170172)

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But, their TMAO AUC increased compared with placebo, representing a directionally opposite response to that observed in female participants of premenopausal age and male participants

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FMD also reversed the accumulation of total CD4+ T cells, particularly CNS-accumulating IFN- -producing CD4+ T cells, induced by EAE