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Similarly, elevated blood pressure has been directly correlated with decreased blood-brain barrier integrity and can compromise concussion rehabilitation outcomes

Effects are characterized in animal models: potent antinociception, catalepsy at higher amounts, and dose-dependent respiratory and blood-pressure changes typical of a mu-opioid

Reverses Certain Signs of Cellular Aging: In animal models, clearing senescent cells has restored hair growth and improved fitness, suggesting a potential to reverse some age-related markers

Potency may decline faster, shortening the usable life of the medication