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PPAR- agonists inhibit NF-B activation and suppress the JAK/STAT pathway to reduce the expression and release of IL-1, IL-6, IL-8, and TNF-, thereby exerting anti-inflammatory effects (119)

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A Randomized, multicenter, open-label, blinded end point, phase 2, feasibility, efficacy, and safety trial of preoperative microvascular protection in patients undergoing major abdominal surgery

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