Frequency and dosage depend on factors like medical condition, response to treatment, age, diet, and overall health
Weekly or bi-weekly for active protocols
Research indicates that reducing NNMT activity with 5-amino-1MQ alters metabolic processes, promotes changes in adipocyte function, and modulates muscle and nerve physiology
Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
Does changing the liquid volume change the total peptide in the vial?+ No
For more on keeping vitamin levels up, even if youre on meds like metformin, check out Mayo Clinics guide to vitamin B12