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Other times, they're invisible until your experiment fails

Insufficient mixing (leaves undissolved particles)

Brain-targeted delivery of docetaxel by glutathione-coated nanoparticles for brain cancer

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Nanoscale 12(14):76047621 Yang MH et al (2017) Anti-angiogenic effect of arsenic trioxide in lung cancer via inhibition of endothelial cell migration, proliferation and tube formation

More likely environmental triggers