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Administration Route# Dihexa has a notable advantage in practical administration: its demonstrated oral bioavailability (approximately 38%) means it can be taken by mouth with meaningful CNS exposure

The ability to target anti-TNF-alpha activity to the intestine could help to thwart these drawbacks and would also allow for higher dosing and thus better disease control

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Accurate reconstitution is vital to ensure that the peptides retain their potency and bioactivity for further trials

Personalized protocols based on genetics, oxidative stress biomarkers and metabolomic profiles will probably surface, allowing clinicians to tailor peptides to the patients unique oxidative and inflammatory fingerprint