Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols
JAMA 290 , 19061914 (2003)
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PubMed Philp, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A.L., Kleinman, H.K