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Completed Phase II and III clinical trials have indicated that the agent has a nonoverlapping toxicity profile and synergistic effects with carboplatin, paclitaxel, and anthracycline, has no cross-drug resistance and is well tolerated, with patients mostly reporting fatigue and nausea

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Properly designed experimental studies and clinical trials that address these inconsistencies are urgently needed

The authors found that patients with peripheral arterial disease were able to walk comfortably for longer times and distances after using PLC

Blood-brain barrier disruption, vascular impairment, and ischemia/reperfusion damage in diabetic stroke