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The mechanism of metabolic acidosis and 5-oxoprolinuria is the following: decreased levels of cellular glutathione lead to decreased feed-back inhibition of -glutamylcysteine synthetase

doi: 10.1016/j.foodres.2022.111572 56

Throughout the study, some participants withdrew, but the dropout rate was lower in the TE 0.5 mg group compared to the placebo or TE 1.0 mg groups

Ceriello A (2003) New insights on oxidative stress and diabetic complications may lead to a causal antioxidant therapy

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Increased FOXO4 expression correlates with enhanced proteasomal activity, leading to a reduction in the accumulation of damaged proteins, particularly in cardiovascular tissue