While the more obvious route would be directly suppressing TNF, that might not be a good idea because of its important roles in fighting infections and other invaders, which is already a concern for current treatments, they say
Miao Z, Jiang S, Ding M, Sun S, Ma Y, Younis MR, et al
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doi:10.1111/j.1468-2494.2009.00490.x
Estrogen receptor signaling mechanisms, in Advances in protein chemistry and structural biology , 135170
Interventions aimed at regulating oxidative stress, restoring antioxidant defenses, chelating iron, and preventing lipid peroxidation are at the forefront of these efforts ( Figure 6 )