Similarly, M1-type microglia exhibit reduced susceptibility to ferroptosis compared to M2-type microglia, likely due to high expression of inducible nitric oxide synthase (iNOS) in M1 cells (381383)
Additionally, reduced ALDH2 expression in liver cancer tissues correlates with increased tumor growth, migration, and poor prognosis, and this deficiency disrupts cellular redox balance and metastatic potential (4244)
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