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Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)
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The combination of MitoQ and DPI with a widely used chemotherapeutic agent allowed to more closely resemble potential clinical treatments for NB patients
This means it doesnt kill bacteria, but it effectively stops them from multiplying
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