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Typical weekly range: 0.64.5 mg once weekly (gradual titration over 46 weeks)

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Aim to take it in the morning or before bed, depending on your routine

The first step (for all OA patients) is following an anti-inflammatory diet (mainly the MD, rich in -3 PUFAs, fruits, vegetables, and whole grains), combined with weight loss of 510% (for those with a BMI 25) and low-impact exercises (such as swimming) for 3 months

The initial reactions of cholesterol synthesis, to the formation of isopentenyl pyrophosphate, are commonly referred to as the mevalonate pathway