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Cerebro-cerebellar circuits in autism spectrum disorder

Supporting NAD+ levels can improve baseline capacity for focus and cognitive control

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This intricate assembly encompasses the NLRP3 protein, serving as a detector for inflammasome activation, and the apoptosis-associated speck-like protein containing the CARD complex (ASC)

Moreover, serum vitamin B12 and homocysteine concentrations were significantly associated with ASD, whereas plasma vitamin B12 and homocysteine concentrations were not statistically different between children with ASD and HC children (eFig

However, a 2025 review noted only 3 RCTs, calling for larger trials (Nguyen et al., 2025)