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Ideal maintenance candidates include: People on plant-based diets who need regular B12 supplementation to prevent gradual depletion

The energy provided by B12 can also reduce the fatigue-driven eating that often undermines caloric restriction

The short answer is, it depends

Slow titration is especially important with compounded formulations because concentration accuracy can vary slightly between batches

But just to get the audience on the same page because the way we could define the evidence being far along or not far along may differ

In fact, SHBG influences insulin signaling, glucose transport, and lipid metabolism, making it a potential biomarker and mechanistic contributor to metabolic dysfunction [26,27,28]