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Two key enzymes, acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3), are involved in the biosynthesis and remodeling of PEs, activation of PUFAs, and insertion of PUFAs into membrane PLs (Kagan et al., 2017), while LPCAT3 preferentially catalyzes the insertion of acylated AA into membrane phospholipids (Kagan et al., 2017)

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