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doi: 10.3390/ijms22030988

The circulating half-life is short approximately 11 to 12 minutes which is why research protocols typically use small subcutaneous doses given at bedtime to align with the natural overnight GH pulse

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A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions

2003 Jul 15;188(2):232-8