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We acknowledge the funding support from the NIH (HL143545- 01A1) and Your Energy Systems and Summer student fellowship from Western University of Health Sciences for Brandon Norris and Abraham Chorbajian

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NLX-112 has shown an acceptable safety profile in a small phase 2a, double-blind trial in 27 PD patients [139]

The outcome of corresponding or similar mutations in humans is described, as well as the potential mechanisms underlying increased longevity and the therapeutic benefits and risks of medical disruption of the GH/IGF-1 axis in humans

However, mutations resulting in antibiotic resistance may happen during the error-prone DNA repair process