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Additionally, environmental factors such as iodine excess or deficiency, smoking, stress, exposure to chemicals, medications (e.g., amiodarone, interferon-), and some viral/bacterial infections can alter gene expression patterns through epigenetic mechanisms and trigger autoimmune processes

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We recently reported that NNMTi treatment combined with a low-fat, or lean, diet (LD) returned systemic adiposity and liver pathologies of obese animals to the adiposity and liver pathology levels of LD controls

doi: 10.1371/journal.pntd.0007450 [DOI] [PMC free article] [PubMed] [Google Scholar] 324

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One similarity they do have, however, is that theyre both alleged to help with longevity, energy and stress resilience